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The pharmacist sends all these prescriptions to the Prescription Pricing Authority, which under conditions of full confidentiality, provides electronic copies of the exposure data to the Drug Safety Research Unit.

Antihistamines make your sleepy by antagonizing central histimine-1 (H-1) receptors in the brain.

The ones you see in over-the-counter sleep aids are usually diphenhydramine and hydroxyzine.

(There are other types of antihistamines that affect H-2, H-3, and H-4 receptors.) People build up tolerance to them over time and when they stop taking them experience rebound insomnia.

To further examine the sedative effects of four commonly prescribed antihistamines—loratadine, cetirizine, fexofenadine, and acrivastine—we analysed the results of four non-interventional observational cohort studies of these drugs performed by the Drug Safety Research Unit.

These studies correlated prescriptions issued in general practice with events reported by the patients to their general practitioners after the drug was dispensed.

Subjects: Event data were obtained for a total of 43 363 patients.

Main outcome measure: Reporting of sedation or drowsiness.

First generation OTC anti-histamines for allergies (active ingredients and brand names): ► Loratadine Claritin ► Cetirizine Zyrtec Indications sneezing, itching, watery eyes and runny nose and hives."In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.Non-sedating antihistamines are helping to improve the lives of countless people who suffer from the symptoms of serious allergic reactions.Doxylamine is one of the most powerful OTC sedatives in the U. Many patients taking doxylamine encounter dry mouth, nausea, and drowsiness.This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.Syrup 5 mg/ 5 m L Loratadine (Claritin, Tavist), Brompheniramine (Dimetane): Tablet 10mg once daily for adults, 5 mg once daily for children 2 to 5 years.Chlorpheniramine (Chlor-Trimeton) 4 mg orally every 4 - 6 hrs; sustained-release: 8 or 12 mg orally every 8 - 12 hours. Diphenhydramine (Benadryl): 25 mg to 50 mg (1-2 capsules) per day for adults and children above 12 years; for children 6 -12 years of age 25 mg (1 capsule) Side effects drowsiness especially in case of first generation antihistamines, restlessness, nervousness, upset stomach, dry mouth, irritability, difficulty urinating and sometimes blurred vision.Doxylamine can be used by itself as a sleep aid or combined with other drugs for cold and allergy relief (usually in a night-time formula).It is sometimes used along with Vitamin B6 to stop morning sickness during pregnancy.There are some things that you should know before you buy or use these medications. Objectives: To investigate the frequency with which sedation was reported in post-marketing surveillance studies of four second generation antihistamines: loratadine, cetirizine, fexofenadine, and acrivastine. Setting: Prescriptions were obtained for each cohort in the immediate post-marketing period.