Children's Research Institute, Research Center for Molecular Physiology, Children's National Medical Center; The George Washington University; and Lombardi Cancer Center, Georgetown University, Washington D.C., USABasic fibroblast growth factor (b FGF) is an angiogenic growth factor that is involved in renal growth and the pathogenesis of renal diseases.Contestants travel to and within multiple countries in a variety of transportation modes, including airplanes, hot air balloons, helicopters, trucks, bicycles, taxicabs, cars, trains, buses, boats, and by foot.Clues provided in each leg lead the teams to the next destination or direct them to perform a task, either together or by a single member.
Teams are progressively eliminated until three are left; at that point, the team that arrives first in the final leg is awarded the grand prize. The show has branched out to include a number of international versions following a similar format.
Western blots and reverse transcriptase-polymerase chain reaction studies were done in selected urine samples and cultured renal cells.
Recombinant FGF-BP was produced to study the mitogenic activity of FGF-BP in cultured human renal proximal tubular epithelial cells (RPTEcs).
The expression of FGF-BP was up-regulated predominately in renal tubular epithelial cells in children with renal tubular injury, HIV-associated nephropathy (HIVAN), and HUS, and FGF-BP was secreted in the urine of these patients.
FGF-BP was also abundantly expressed in developing fetal renal tubules.